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Merkazolil Brand names, Merkazolil Analogs

Merkazolil Brand Names Mixture

  • No information avaliable

Merkazolil Chemical_Formula


Merkazolil RX_link

Merkazolil fda sheet

Merkazolil msds (material safety sheet)

Merkazolil MSDS

Merkazolil Synthesis Reference

No information avaliable

Merkazolil Molecular Weight

114.17 g/mol

Merkazolil Melting Point

146 oC

Merkazolil H2O Solubility

275 g/L

Merkazolil State


Merkazolil LogP


Merkazolil Dosage Forms

Tablet (5 or 10 mg)

Merkazolil Indication

For the treatment of hyperthyroidism, goiter, Graves disease and psoriasis.

Merkazolil Pharmacology

Used in the treatment of hyperthyroidism or an overactive thyroid gland, methimazole inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. It may also be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy.

Merkazolil Absorption

Rapid with an oral bioavailability of 93%.

Merkazolil side effects and Toxicity

Oral LD50 in rats is 2250 mg/kg. Symptoms of overdose include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancy-topenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression.

Merkazolil Patient Information

Patients should be instructed to report to their physicians any symptoms of agranulocytosis, such as fever or sore throat.

Merkazolil Organisms Affected

Humans and other mammals