Thiamazol
Thiamazol Brand names, Thiamazol Analogs
- Basolan
- Danantizol
- Favistan
- Frentirox
- Mercaptazole
- Mercasolyl
- Mercazole
- Mercazolyl
- Merkastan
- Merkazolil
- Metazolo
- Methamazole
- Methiamazole
- Methimazol
- Methylmercaptoimidazole
- Metizol
- Metothyrin
- Metothyrine
- Metotirin
- Propyl-Thyracil
- Strumazol
- Strumazole
- Tapazole
- Tapuzole
- Thacapzol
- Thiamazol
- Thiamazole
- Thimazole
- Thycapsol
- Thycapzol
- Thymidazol
- Thymidazole
- USAF EL-30
Thiamazol Brand Names Mixture
- No information avaliable
Thiamazol Chemical_Formula
C4H6N2S
Thiamazol RX_link
http://www.rxlist.com/cgi/generic3/methim.htm
Thiamazol fda sheet
Thiamazol msds (material safety sheet)
Thiamazol Synthesis Reference
No information avaliable
Thiamazol Molecular Weight
114.17 g/mol
Thiamazol Melting Point
146 oC
Thiamazol H2O Solubility
275 g/L
Thiamazol State
Solid
Thiamazol LogP
-0.34
Thiamazol Dosage Forms
Tablet (5 or 10 mg)
Thiamazol Indication
For the treatment of hyperthyroidism, goiter, Graves disease and psoriasis.
Thiamazol Pharmacology
Used in the treatment of hyperthyroidism or an overactive thyroid gland, methimazole inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. It may also be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy.
Thiamazol Absorption
Rapid with an oral bioavailability of 93%.
Thiamazol side effects and Toxicity
Oral LD50 in rats is 2250 mg/kg. Symptoms of overdose include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancy-topenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression.
Thiamazol Patient Information
Patients should be instructed to report to their physicians any symptoms of agranulocytosis, such as fever or sore throat.
Thiamazol Organisms Affected
Humans and other mammals
