Metotirin
Metotirin Brand names, Metotirin Analogs
- Basolan
- Danantizol
- Favistan
- Frentirox
- Mercaptazole
- Mercasolyl
- Mercazole
- Mercazolyl
- Merkastan
- Merkazolil
- Metazolo
- Methamazole
- Methiamazole
- Methimazol
- Methylmercaptoimidazole
- Metizol
- Metothyrin
- Metothyrine
- Metotirin
- Propyl-Thyracil
- Strumazol
- Strumazole
- Tapazole
- Tapuzole
- Thacapzol
- Thiamazol
- Thiamazole
- Thimazole
- Thycapsol
- Thycapzol
- Thymidazol
- Thymidazole
- USAF EL-30
Metotirin Brand Names Mixture
- No information avaliable
Metotirin Chemical_Formula
C4H6N2S
Metotirin RX_link
http://www.rxlist.com/cgi/generic3/methim.htm
Metotirin fda sheet
Metotirin msds (material safety sheet)
Metotirin Synthesis Reference
No information avaliable
Metotirin Molecular Weight
114.17 g/mol
Metotirin Melting Point
146 oC
Metotirin H2O Solubility
275 g/L
Metotirin State
Solid
Metotirin LogP
-0.34
Metotirin Dosage Forms
Tablet (5 or 10 mg)
Metotirin Indication
For the treatment of hyperthyroidism, goiter, Graves disease and psoriasis.
Metotirin Pharmacology
Used in the treatment of hyperthyroidism or an overactive thyroid gland, methimazole inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. It may also be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy.
Metotirin Absorption
Rapid with an oral bioavailability of 93%.
Metotirin side effects and Toxicity
Oral LD50 in rats is 2250 mg/kg. Symptoms of overdose include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancy-topenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression.
Metotirin Patient Information
Patients should be instructed to report to their physicians any symptoms of agranulocytosis, such as fever or sore throat.
Metotirin Organisms Affected
Humans and other mammals
