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Metotirin Brand names, Metotirin Analogs

Metotirin Brand Names Mixture

  • No information avaliable

Metotirin Chemical_Formula


Metotirin RX_link

Metotirin fda sheet

Metotirin msds (material safety sheet)

Metotirin MSDS

Metotirin Synthesis Reference

No information avaliable

Metotirin Molecular Weight

114.17 g/mol

Metotirin Melting Point

146 oC

Metotirin H2O Solubility

275 g/L

Metotirin State


Metotirin LogP


Metotirin Dosage Forms

Tablet (5 or 10 mg)

Metotirin Indication

For the treatment of hyperthyroidism, goiter, Graves disease and psoriasis.

Metotirin Pharmacology

Used in the treatment of hyperthyroidism or an overactive thyroid gland, methimazole inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. It may also be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy.

Metotirin Absorption

Rapid with an oral bioavailability of 93%.

Metotirin side effects and Toxicity

Oral LD50 in rats is 2250 mg/kg. Symptoms of overdose include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancy-topenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression.

Metotirin Patient Information

Patients should be instructed to report to their physicians any symptoms of agranulocytosis, such as fever or sore throat.

Metotirin Organisms Affected

Humans and other mammals