Tapuzole
Tapuzole Brand names, Tapuzole Analogs
- Basolan
- Danantizol
- Favistan
- Frentirox
- Mercaptazole
- Mercasolyl
- Mercazole
- Mercazolyl
- Merkastan
- Merkazolil
- Metazolo
- Methamazole
- Methiamazole
- Methimazol
- Methylmercaptoimidazole
- Metizol
- Metothyrin
- Metothyrine
- Metotirin
- Propyl-Thyracil
- Strumazol
- Strumazole
- Tapazole
- Tapuzole
- Thacapzol
- Thiamazol
- Thiamazole
- Thimazole
- Thycapsol
- Thycapzol
- Thymidazol
- Thymidazole
- USAF EL-30
Tapuzole Brand Names Mixture
- No information avaliable
Tapuzole Chemical_Formula
C4H6N2S
Tapuzole RX_link
http://www.rxlist.com/cgi/generic3/methim.htm
Tapuzole fda sheet
Tapuzole msds (material safety sheet)
Tapuzole Synthesis Reference
No information avaliable
Tapuzole Molecular Weight
114.17 g/mol
Tapuzole Melting Point
146 oC
Tapuzole H2O Solubility
275 g/L
Tapuzole State
Solid
Tapuzole LogP
-0.34
Tapuzole Dosage Forms
Tablet (5 or 10 mg)
Tapuzole Indication
For the treatment of hyperthyroidism, goiter, Graves disease and psoriasis.
Tapuzole Pharmacology
Used in the treatment of hyperthyroidism or an overactive thyroid gland, methimazole inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. It may also be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy.
Tapuzole Absorption
Rapid with an oral bioavailability of 93%.
Tapuzole side effects and Toxicity
Oral LD50 in rats is 2250 mg/kg. Symptoms of overdose include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancy-topenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression.
Tapuzole Patient Information
Patients should be instructed to report to their physicians any symptoms of agranulocytosis, such as fever or sore throat.
Tapuzole Organisms Affected
Humans and other mammals
