Mercazole
Mercazole Brand names, Mercazole Analogs
- Basolan
- Danantizol
- Favistan
- Frentirox
- Mercaptazole
- Mercasolyl
- Mercazole
- Mercazolyl
- Merkastan
- Merkazolil
- Metazolo
- Methamazole
- Methiamazole
- Methimazol
- Methylmercaptoimidazole
- Metizol
- Metothyrin
- Metothyrine
- Metotirin
- Propyl-Thyracil
- Strumazol
- Strumazole
- Tapazole
- Tapuzole
- Thacapzol
- Thiamazol
- Thiamazole
- Thimazole
- Thycapsol
- Thycapzol
- Thymidazol
- Thymidazole
- USAF EL-30
Mercazole Brand Names Mixture
- No information avaliable
Mercazole Chemical_Formula
C4H6N2S
Mercazole RX_link
http://www.rxlist.com/cgi/generic3/methim.htm
Mercazole fda sheet
Mercazole msds (material safety sheet)
Mercazole Synthesis Reference
No information avaliable
Mercazole Molecular Weight
114.17 g/mol
Mercazole Melting Point
146 oC
Mercazole H2O Solubility
275 g/L
Mercazole State
Solid
Mercazole LogP
-0.34
Mercazole Dosage Forms
Tablet (5 or 10 mg)
Mercazole Indication
For the treatment of hyperthyroidism, goiter, Graves disease and psoriasis.
Mercazole Pharmacology
Used in the treatment of hyperthyroidism or an overactive thyroid gland, methimazole inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. It may also be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy.
Mercazole Absorption
Rapid with an oral bioavailability of 93%.
Mercazole side effects and Toxicity
Oral LD50 in rats is 2250 mg/kg. Symptoms of overdose include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancy-topenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression.
Mercazole Patient Information
Patients should be instructed to report to their physicians any symptoms of agranulocytosis, such as fever or sore throat.
Mercazole Organisms Affected
Humans and other mammals
