Mercaptazole
Mercaptazole Brand names, Mercaptazole Analogs
- Basolan
- Danantizol
- Favistan
- Frentirox
- Mercaptazole
- Mercasolyl
- Mercazole
- Mercazolyl
- Merkastan
- Merkazolil
- Metazolo
- Methamazole
- Methiamazole
- Methimazol
- Methylmercaptoimidazole
- Metizol
- Metothyrin
- Metothyrine
- Metotirin
- Propyl-Thyracil
- Strumazol
- Strumazole
- Tapazole
- Tapuzole
- Thacapzol
- Thiamazol
- Thiamazole
- Thimazole
- Thycapsol
- Thycapzol
- Thymidazol
- Thymidazole
- USAF EL-30
Mercaptazole Brand Names Mixture
- No information avaliable
Mercaptazole Chemical_Formula
C4H6N2S
Mercaptazole RX_link
http://www.rxlist.com/cgi/generic3/methim.htm
Mercaptazole fda sheet
Mercaptazole msds (material safety sheet)
Mercaptazole Synthesis Reference
No information avaliable
Mercaptazole Molecular Weight
114.17 g/mol
Mercaptazole Melting Point
146 oC
Mercaptazole H2O Solubility
275 g/L
Mercaptazole State
Solid
Mercaptazole LogP
-0.34
Mercaptazole Dosage Forms
Tablet (5 or 10 mg)
Mercaptazole Indication
For the treatment of hyperthyroidism, goiter, Graves disease and psoriasis.
Mercaptazole Pharmacology
Used in the treatment of hyperthyroidism or an overactive thyroid gland, methimazole inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. It may also be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy.
Mercaptazole Absorption
Rapid with an oral bioavailability of 93%.
Mercaptazole side effects and Toxicity
Oral LD50 in rats is 2250 mg/kg. Symptoms of overdose include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancy-topenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression.
Mercaptazole Patient Information
Patients should be instructed to report to their physicians any symptoms of agranulocytosis, such as fever or sore throat.
Mercaptazole Organisms Affected
Humans and other mammals
