Methylmercaptoimidazole
Methylmercaptoimidazole Brand names, Methylmercaptoimidazole Analogs
- Basolan
- Danantizol
- Favistan
- Frentirox
- Mercaptazole
- Mercasolyl
- Mercazole
- Mercazolyl
- Merkastan
- Merkazolil
- Metazolo
- Methamazole
- Methiamazole
- Methimazol
- Methylmercaptoimidazole
- Metizol
- Metothyrin
- Metothyrine
- Metotirin
- Propyl-Thyracil
- Strumazol
- Strumazole
- Tapazole
- Tapuzole
- Thacapzol
- Thiamazol
- Thiamazole
- Thimazole
- Thycapsol
- Thycapzol
- Thymidazol
- Thymidazole
- USAF EL-30
Methylmercaptoimidazole Brand Names Mixture
- No information avaliable
Methylmercaptoimidazole Chemical_Formula
C4H6N2S
Methylmercaptoimidazole RX_link
http://www.rxlist.com/cgi/generic3/methim.htm
Methylmercaptoimidazole fda sheet
Methylmercaptoimidazole msds (material safety sheet)
Methylmercaptoimidazole Synthesis Reference
No information avaliable
Methylmercaptoimidazole Molecular Weight
114.17 g/mol
Methylmercaptoimidazole Melting Point
146 oC
Methylmercaptoimidazole H2O Solubility
275 g/L
Methylmercaptoimidazole State
Solid
Methylmercaptoimidazole LogP
-0.34
Methylmercaptoimidazole Dosage Forms
Tablet (5 or 10 mg)
Methylmercaptoimidazole Indication
For the treatment of hyperthyroidism, goiter, Graves disease and psoriasis.
Methylmercaptoimidazole Pharmacology
Used in the treatment of hyperthyroidism or an overactive thyroid gland, methimazole inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. It may also be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy.
Methylmercaptoimidazole Absorption
Rapid with an oral bioavailability of 93%.
Methylmercaptoimidazole side effects and Toxicity
Oral LD50 in rats is 2250 mg/kg. Symptoms of overdose include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancy-topenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression.
Methylmercaptoimidazole Patient Information
Patients should be instructed to report to their physicians any symptoms of agranulocytosis, such as fever or sore throat.
Methylmercaptoimidazole Organisms Affected
Humans and other mammals
