THA
THA Brand names, THA Analogs
- Basolan
- Danantizol
- Favistan
- Frentirox
- Mercaptazole
- Mercasolyl
- Mercazole
- Mercazolyl
- Merkastan
- Merkazolil
- Metazolo
- Methamazole
- Methiamazole
- Methimazol
- Methylmercaptoimidazole
- Metizol
- Metothyrin
- Metothyrine
- Metotirin
- Propyl-Thyracil
- Strumazol
- Strumazole
- Tapazole
- Tapuzole
- Thacapzol
- Thiamazol
- Thiamazole
- Thimazole
- Thycapsol
- Thycapzol
- Thymidazol
- Thymidazole
- USAF EL-30
THA Brand Names Mixture
- No information avaliable
THA Chemical_Formula
C4H6N2S
THA RX_link
http://www.rxlist.com/cgi/generic3/methim.htm
THA fda sheet
THA msds (material safety sheet)
THA Synthesis Reference
No information avaliable
THA Molecular Weight
114.17 g/mol
THA Melting Point
146 oC
THA H2O Solubility
275 g/L
THA State
Solid
THA LogP
-0.34
THA Dosage Forms
Tablet (5 or 10 mg)
THA Indication
For the treatment of hyperthyroidism, goiter, Graves disease and psoriasis.
THA Pharmacology
Used in the treatment of hyperthyroidism or an overactive thyroid gland, methimazole inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. It may also be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy.
THA Absorption
Rapid with an oral bioavailability of 93%.
THA side effects and Toxicity
Oral LD50 in rats is 2250 mg/kg. Symptoms of overdose include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancy-topenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression.
THA Patient Information
Patients should be instructed to report to their physicians any symptoms of agranulocytosis, such as fever or sore throat.
THA Organisms Affected
Humans and other mammals
