Propasa
Brand names,
Propasa
Analogs
Propasa
Brand Names Mixture
Propasa
Chemical_Formula
C7H7NO3
Propasa
RX_link
http://www.rxlist.com/cgi/generic2/paser.htm
Propasa
fda sheet
Propasa
msds (material safety sheet)
Propasa
Synthesis Reference
Biniecki S., et al. Acta Pol Pharm. 1967;24(5):469-73
Propasa
Molecular Weight
153.135 g/mol
Propasa
Melting Point
150.5 oC
Propasa
H2O Solubility
1690 mg/L
Propasa
State
Solid
Propasa
LogP
1.012
Propasa
Dosage Forms
Packet of coated granules
Propasa
Indication
For the treatment of tuberculosis
Propasa
Pharmacology
Aminosalicylic acid is an anti-mycobacterial agent used with other anti-tuberculosis drugs (most often isoniazid) for the treatment of all forms of active tuberculosis due to susceptible strains of tubercle bacilli. The two major considerations in the clinical pharmacology of aminosalicylic acid are the prompt production of a toxic inactive metabolite under acid conditions and the short serum half life of one hour for the free drug. Aminosalicylic acid is bacteriostatic against Mycobacterium tuberculosis (prevents the multiplying of bacteria without destroying them). It also inhibits the onset of bacterial resistance to streptomycin and isoniazid.
Propasa
Absorption
No information avaliable
Propasa
side effects and Toxicity
LD50=4 gm/kg (orally in mice); LD50=3650 mg/kg (orally in rabbits)
Propasa
Patient Information
Propasa
Organisms Affected
Mycobacteria