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Pasem Brand names, Pasem Analogs

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  • No information avaliable

Pasem Chemical_Formula


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Pasem Synthesis Reference

Biniecki S., et al. Acta Pol Pharm. 1967;24(5):469-73

Pasem Molecular Weight

153.135 g/mol

Pasem Melting Point

150.5 oC

Pasem H2O Solubility

1690 mg/L

Pasem State


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Pasem Dosage Forms

Packet of coated granules

Pasem Indication

For the treatment of tuberculosis

Pasem Pharmacology

Aminosalicylic acid is an anti-mycobacterial agent used with other anti-tuberculosis drugs (most often isoniazid) for the treatment of all forms of active tuberculosis due to susceptible strains of tubercle bacilli. The two major considerations in the clinical pharmacology of aminosalicylic acid are the prompt production of a toxic inactive metabolite under acid conditions and the short serum half life of one hour for the free drug. Aminosalicylic acid is bacteriostatic against Mycobacterium tuberculosis (prevents the multiplying of bacteria without destroying them). It also inhibits the onset of bacterial resistance to streptomycin and isoniazid.

Pasem Absorption

No information avaliable

Pasem side effects and Toxicity

LD50=4 gm/kg (orally in mice); LD50=3650 mg/kg (orally in rabbits)

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