Neopasalate
Brand names,
Neopasalate
Analogs
Neopasalate
Brand Names Mixture
Neopasalate
Chemical_Formula
C7H7NO3
Neopasalate
RX_link
http://www.rxlist.com/cgi/generic2/paser.htm
Neopasalate
fda sheet
Neopasalate
msds (material safety sheet)
Neopasalate
Synthesis Reference
Biniecki S., et al. Acta Pol Pharm. 1967;24(5):469-73
Neopasalate
Molecular Weight
153.135 g/mol
Neopasalate
Melting Point
150.5 oC
Neopasalate
H2O Solubility
1690 mg/L
Neopasalate
State
Solid
Neopasalate
LogP
1.012
Neopasalate
Dosage Forms
Packet of coated granules
Neopasalate
Indication
For the treatment of tuberculosis
Neopasalate
Pharmacology
Aminosalicylic acid is an anti-mycobacterial agent used with other anti-tuberculosis drugs (most often isoniazid) for the treatment of all forms of active tuberculosis due to susceptible strains of tubercle bacilli. The two major considerations in the clinical pharmacology of aminosalicylic acid are the prompt production of a toxic inactive metabolite under acid conditions and the short serum half life of one hour for the free drug. Aminosalicylic acid is bacteriostatic against Mycobacterium tuberculosis (prevents the multiplying of bacteria without destroying them). It also inhibits the onset of bacterial resistance to streptomycin and isoniazid.
Neopasalate
Absorption
No information avaliable
Neopasalate
side effects and Toxicity
LD50=4 gm/kg (orally in mice); LD50=3650 mg/kg (orally in rabbits)
Neopasalate
Patient Information
Neopasalate
Organisms Affected
Mycobacteria