Aminosalicylate Sodium
Brand names,
Aminosalicylate Sodium
Analogs
Aminosalicylate Sodium
Brand Names Mixture
Aminosalicylate Sodium
Chemical_Formula
C7H7NO3
Aminosalicylate Sodium
RX_link
http://www.rxlist.com/cgi/generic2/paser.htm
Aminosalicylate Sodium
fda sheet
Aminosalicylate Sodium
msds (material safety sheet)
Aminosalicylate Sodium
Synthesis Reference
Biniecki S., et al. Acta Pol Pharm. 1967;24(5):469-73
Aminosalicylate Sodium
Molecular Weight
153.135 g/mol
Aminosalicylate Sodium
Melting Point
150.5 oC
Aminosalicylate Sodium
H2O Solubility
1690 mg/L
Aminosalicylate Sodium
State
Solid
Aminosalicylate Sodium
LogP
1.012
Aminosalicylate Sodium
Dosage Forms
Packet of coated granules
Aminosalicylate Sodium
Indication
For the treatment of tuberculosis
Aminosalicylate Sodium
Pharmacology
Aminosalicylic acid is an anti-mycobacterial agent used with other anti-tuberculosis drugs (most often isoniazid) for the treatment of all forms of active tuberculosis due to susceptible strains of tubercle bacilli. The two major considerations in the clinical pharmacology of aminosalicylic acid are the prompt production of a toxic inactive metabolite under acid conditions and the short serum half life of one hour for the free drug. Aminosalicylic acid is bacteriostatic against Mycobacterium tuberculosis (prevents the multiplying of bacteria without destroying them). It also inhibits the onset of bacterial resistance to streptomycin and isoniazid.
Aminosalicylate Sodium
Absorption
No information avaliable
Aminosalicylate Sodium
side effects and Toxicity
LD50=4 gm/kg (orally in mice); LD50=3650 mg/kg (orally in rabbits)
Aminosalicylate Sodium
Patient Information
Aminosalicylate Sodium
Organisms Affected
Mycobacteria