Parasal
Brand names,
Parasal
Analogs
Parasal
Brand Names Mixture
Parasal
Chemical_Formula
C7H7NO3
Parasal
RX_link
http://www.rxlist.com/cgi/generic2/paser.htm
Parasal
fda sheet
Parasal
msds (material safety sheet)
Parasal
Synthesis Reference
Biniecki S., et al. Acta Pol Pharm. 1967;24(5):469-73
Parasal
Molecular Weight
153.135 g/mol
Parasal
Melting Point
150.5 oC
Parasal
H2O Solubility
1690 mg/L
Parasal
State
Solid
Parasal
LogP
1.012
Parasal
Dosage Forms
Packet of coated granules
Parasal
Indication
For the treatment of tuberculosis
Parasal
Pharmacology
Aminosalicylic acid is an anti-mycobacterial agent used with other anti-tuberculosis drugs (most often isoniazid) for the treatment of all forms of active tuberculosis due to susceptible strains of tubercle bacilli. The two major considerations in the clinical pharmacology of aminosalicylic acid are the prompt production of a toxic inactive metabolite under acid conditions and the short serum half life of one hour for the free drug. Aminosalicylic acid is bacteriostatic against Mycobacterium tuberculosis (prevents the multiplying of bacteria without destroying them). It also inhibits the onset of bacterial resistance to streptomycin and isoniazid.
Parasal
Absorption
No information avaliable
Parasal
side effects and Toxicity
LD50=4 gm/kg (orally in mice); LD50=3650 mg/kg (orally in rabbits)
Parasal
Patient Information
Parasal
Organisms Affected
Mycobacteria