Pasalon
Brand names,
Pasalon
Analogs
Pasalon
Brand Names Mixture
Pasalon
Chemical_Formula
C7H7NO3
Pasalon
RX_link
http://www.rxlist.com/cgi/generic2/paser.htm
Pasalon
fda sheet
Pasalon
msds (material safety sheet)
Pasalon
Synthesis Reference
Biniecki S., et al. Acta Pol Pharm. 1967;24(5):469-73
Pasalon
Molecular Weight
153.135 g/mol
Pasalon
Melting Point
150.5 oC
Pasalon
H2O Solubility
1690 mg/L
Pasalon
State
Solid
Pasalon
LogP
1.012
Pasalon
Dosage Forms
Packet of coated granules
Pasalon
Indication
For the treatment of tuberculosis
Pasalon
Pharmacology
Aminosalicylic acid is an anti-mycobacterial agent used with other anti-tuberculosis drugs (most often isoniazid) for the treatment of all forms of active tuberculosis due to susceptible strains of tubercle bacilli. The two major considerations in the clinical pharmacology of aminosalicylic acid are the prompt production of a toxic inactive metabolite under acid conditions and the short serum half life of one hour for the free drug. Aminosalicylic acid is bacteriostatic against Mycobacterium tuberculosis (prevents the multiplying of bacteria without destroying them). It also inhibits the onset of bacterial resistance to streptomycin and isoniazid.
Pasalon
Absorption
No information avaliable
Pasalon
side effects and Toxicity
LD50=4 gm/kg (orally in mice); LD50=3650 mg/kg (orally in rabbits)
Pasalon
Patient Information
Pasalon
Organisms Affected
Mycobacteria