Apacil
Apacil Brand names, Apacil Analogs
- Aminosalicylate Sodium
- Amino-Pas
- Aminopar
- Aminox
- Apacil
- Apas
- Deapasil
- Entepas
- Ferrosan
- Gabbropas
- Hellipidyl
- Kyselina P-Aminosalicylova
- Neopasalate
- Osacyl
- P-Aminosalicylic Acid
- PAS
- PAS-C
- PASK
- Pamacyl
- Pamisyl
- Para-Amino Salicylic Acid
- Para-Pas
- Paramycin
- Parasal
- Parasalicil
- Parasalindon
- Pasa
- Pasalon
- Pasara
- Pascorbic
- Pasdium
- Pasem
- Paser
- Pasmed
- Pasnodia
- Pasolac
- Propasa
- Rezipas
- Sanipirol-4
- Sanipriol-4
Apacil Brand Names Mixture
- No information avaliable
Apacil Chemical_Formula
C7H7NO3
Apacil RX_link
http://www.rxlist.com/cgi/generic2/paser.htm
Apacil fda sheet
Apacil msds (material safety sheet)
Apacil Synthesis Reference
Biniecki S., et al. Acta Pol Pharm. 1967;24(5):469-73
Apacil Molecular Weight
153.135 g/mol
Apacil Melting Point
150.5 oC
Apacil H2O Solubility
1690 mg/L
Apacil State
Solid
Apacil LogP
1.012
Apacil Dosage Forms
Packet of coated granules
Apacil Indication
For the treatment of tuberculosis
Apacil Pharmacology
Aminosalicylic acid is an anti-mycobacterial agent used with other anti-tuberculosis drugs (most often isoniazid) for the treatment of all forms of active tuberculosis due to susceptible strains of tubercle bacilli. The two major considerations in the clinical pharmacology of aminosalicylic acid are the prompt production of a toxic inactive metabolite under acid conditions and the short serum half life of one hour for the free drug. Aminosalicylic acid is bacteriostatic against Mycobacterium tuberculosis (prevents the multiplying of bacteria without destroying them). It also inhibits the onset of bacterial resistance to streptomycin and isoniazid.
Apacil Absorption
No information avaliable
Apacil side effects and Toxicity
LD50=4 gm/kg (orally in mice); LD50=3650 mg/kg (orally in rabbits)
Apacil Patient Information
Apacil Organisms Affected
Mycobacteria
