Gabbropas
Brand names,
Gabbropas
Analogs
Gabbropas
Brand Names Mixture
Gabbropas
Chemical_Formula
C7H7NO3
Gabbropas
RX_link
http://www.rxlist.com/cgi/generic2/paser.htm
Gabbropas
fda sheet
Gabbropas
msds (material safety sheet)
Gabbropas
Synthesis Reference
Biniecki S., et al. Acta Pol Pharm. 1967;24(5):469-73
Gabbropas
Molecular Weight
153.135 g/mol
Gabbropas
Melting Point
150.5 oC
Gabbropas
H2O Solubility
1690 mg/L
Gabbropas
State
Solid
Gabbropas
LogP
1.012
Gabbropas
Dosage Forms
Packet of coated granules
Gabbropas
Indication
For the treatment of tuberculosis
Gabbropas
Pharmacology
Aminosalicylic acid is an anti-mycobacterial agent used with other anti-tuberculosis drugs (most often isoniazid) for the treatment of all forms of active tuberculosis due to susceptible strains of tubercle bacilli. The two major considerations in the clinical pharmacology of aminosalicylic acid are the prompt production of a toxic inactive metabolite under acid conditions and the short serum half life of one hour for the free drug. Aminosalicylic acid is bacteriostatic against Mycobacterium tuberculosis (prevents the multiplying of bacteria without destroying them). It also inhibits the onset of bacterial resistance to streptomycin and isoniazid.
Gabbropas
Absorption
No information avaliable
Gabbropas
side effects and Toxicity
LD50=4 gm/kg (orally in mice); LD50=3650 mg/kg (orally in rabbits)
Gabbropas
Patient Information
Gabbropas
Organisms Affected
Mycobacteria