Epsilcapramine
Epsilcapramine Brand names, Epsilcapramine Analogs
Epsilcapramine Brand Names Mixture
- No information avaliable
Epsilcapramine Chemical_Formula
C6H13NO2
Epsilcapramine RX_link
http://www.rxlist.com/cgi/generic/amicarpre.htm
Epsilcapramine fda sheet
Epsilcapramine msds (material safety sheet)
Epsilcapramine Synthesis Reference
No information avaliable
Epsilcapramine Molecular Weight
131.173 g/mol
Epsilcapramine Melting Point
205 oC
Epsilcapramine H2O Solubility
5.05E+005 mg/L
Epsilcapramine State
Solid
Epsilcapramine LogP
0.306
Epsilcapramine Dosage Forms
Solution for injection (containing 250 mg/mL of aminocaproic acid) and tablets (500, 1000mg)
Epsilcapramine Indication
For use in the treatment of excessive postoperative bleeding.
Epsilcapramine Pharmacology
Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity.
Epsilcapramine Absorption
Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).
Epsilcapramine side effects and Toxicity
A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD50 were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.
Epsilcapramine Patient Information
Epsilcapramine Organisms Affected
Humans and other mammals
