Aminokapron
Aminokapron Brand names, Aminokapron Analogs
Aminokapron Brand Names Mixture
- No information avaliable
Aminokapron Chemical_Formula
C6H13NO2
Aminokapron RX_link
http://www.rxlist.com/cgi/generic/amicarpre.htm
Aminokapron fda sheet
Aminokapron msds (material safety sheet)
Aminokapron Synthesis Reference
No information avaliable
Aminokapron Molecular Weight
131.173 g/mol
Aminokapron Melting Point
205 oC
Aminokapron H2O Solubility
5.05E+005 mg/L
Aminokapron State
Solid
Aminokapron LogP
0.306
Aminokapron Dosage Forms
Solution for injection (containing 250 mg/mL of aminocaproic acid) and tablets (500, 1000mg)
Aminokapron Indication
For use in the treatment of excessive postoperative bleeding.
Aminokapron Pharmacology
Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity.
Aminokapron Absorption
Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).
Aminokapron side effects and Toxicity
A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD50 were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.
Aminokapron Patient Information
Aminokapron Organisms Affected
Humans and other mammals
