Acepramin
Acepramin Brand names, Acepramin Analogs
Acepramin Brand Names Mixture
- No information avaliable
Acepramin Chemical_Formula
C6H13NO2
Acepramin RX_link
http://www.rxlist.com/cgi/generic/amicarpre.htm
Acepramin fda sheet
Acepramin msds (material safety sheet)
Acepramin Synthesis Reference
No information avaliable
Acepramin Molecular Weight
131.173 g/mol
Acepramin Melting Point
205 oC
Acepramin H2O Solubility
5.05E+005 mg/L
Acepramin State
Solid
Acepramin LogP
0.306
Acepramin Dosage Forms
Solution for injection (containing 250 mg/mL of aminocaproic acid) and tablets (500, 1000mg)
Acepramin Indication
For use in the treatment of excessive postoperative bleeding.
Acepramin Pharmacology
Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity.
Acepramin Absorption
Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).
Acepramin side effects and Toxicity
A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD50 were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.
Acepramin Patient Information
Acepramin Organisms Affected
Humans and other mammals
