Respramin
Respramin Brand names, Respramin Analogs
Respramin Brand Names Mixture
- No information avaliable
Respramin Chemical_Formula
C6H13NO2
Respramin RX_link
http://www.rxlist.com/cgi/generic/amicarpre.htm
Respramin fda sheet
Respramin msds (material safety sheet)
Respramin Synthesis Reference
No information avaliable
Respramin Molecular Weight
131.173 g/mol
Respramin Melting Point
205 oC
Respramin H2O Solubility
5.05E+005 mg/L
Respramin State
Solid
Respramin LogP
0.306
Respramin Dosage Forms
Solution for injection (containing 250 mg/mL of aminocaproic acid) and tablets (500, 1000mg)
Respramin Indication
For use in the treatment of excessive postoperative bleeding.
Respramin Pharmacology
Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity.
Respramin Absorption
Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).
Respramin side effects and Toxicity
A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD50 were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.
Respramin Patient Information
Respramin Organisms Affected
Humans and other mammals
