Atsemin
Atsemin Brand names, Atsemin Analogs
Atsemin Brand Names Mixture
- No information avaliable
Atsemin Chemical_Formula
C6H13NO2
Atsemin RX_link
http://www.rxlist.com/cgi/generic/amicarpre.htm
Atsemin fda sheet
Atsemin msds (material safety sheet)
Atsemin Synthesis Reference
No information avaliable
Atsemin Molecular Weight
131.173 g/mol
Atsemin Melting Point
205 oC
Atsemin H2O Solubility
5.05E+005 mg/L
Atsemin State
Solid
Atsemin LogP
0.306
Atsemin Dosage Forms
Solution for injection (containing 250 mg/mL of aminocaproic acid) and tablets (500, 1000mg)
Atsemin Indication
For use in the treatment of excessive postoperative bleeding.
Atsemin Pharmacology
Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity.
Atsemin Absorption
Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).
Atsemin side effects and Toxicity
A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD50 were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.
Atsemin Patient Information
Atsemin Organisms Affected
Humans and other mammals
