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EACS Brand names, EACS Analogs

EACS Brand Names Mixture

  • No information avaliable

EACS Chemical_Formula


EACS RX_link


EACS fda sheet


EACS msds (material safety sheet)


EACS Synthesis Reference

No information avaliable

EACS Molecular Weight

131.173 g/mol

EACS Melting Point

205 oC

EACS H2O Solubility

5.05E+005 mg/L

EACS State




EACS Dosage Forms

Solution for injection (containing 250 mg/mL of aminocaproic acid) and tablets (500, 1000mg)

EACS Indication

For use in the treatment of excessive postoperative bleeding.

EACS Pharmacology

Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity.

EACS Absorption

Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).

EACS side effects and Toxicity

A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD50 were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.

EACS Patient Information

EACS Organisms Affected

Humans and other mammals