Afibrin
Afibrin Brand names, Afibrin Analogs
Afibrin Brand Names Mixture
- No information avaliable
Afibrin Chemical_Formula
C6H13NO2
Afibrin RX_link
http://www.rxlist.com/cgi/generic/amicarpre.htm
Afibrin fda sheet
Afibrin msds (material safety sheet)
Afibrin Synthesis Reference
No information avaliable
Afibrin Molecular Weight
131.173 g/mol
Afibrin Melting Point
205 oC
Afibrin H2O Solubility
5.05E+005 mg/L
Afibrin State
Solid
Afibrin LogP
0.306
Afibrin Dosage Forms
Solution for injection (containing 250 mg/mL of aminocaproic acid) and tablets (500, 1000mg)
Afibrin Indication
For use in the treatment of excessive postoperative bleeding.
Afibrin Pharmacology
Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity.
Afibrin Absorption
Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).
Afibrin side effects and Toxicity
A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD50 were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.
Afibrin Patient Information
Afibrin Organisms Affected
Humans and other mammals
