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Afibrin Brand names, Afibrin Analogs

Afibrin Brand Names Mixture

  • No information avaliable

Afibrin Chemical_Formula


Afibrin RX_link

Afibrin fda sheet

Afibrin FDA

Afibrin msds (material safety sheet)

Afibrin MSDS

Afibrin Synthesis Reference

No information avaliable

Afibrin Molecular Weight

131.173 g/mol

Afibrin Melting Point

205 oC

Afibrin H2O Solubility

5.05E+005 mg/L

Afibrin State


Afibrin LogP


Afibrin Dosage Forms

Solution for injection (containing 250 mg/mL of aminocaproic acid) and tablets (500, 1000mg)

Afibrin Indication

For use in the treatment of excessive postoperative bleeding.

Afibrin Pharmacology

Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity.

Afibrin Absorption

Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).

Afibrin side effects and Toxicity

A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD50 were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.

Afibrin Patient Information

Afibrin Organisms Affected

Humans and other mammals