Epsilcapramin
Epsilcapramin Brand names, Epsilcapramin Analogs
Epsilcapramin Brand Names Mixture
- No information avaliable
Epsilcapramin Chemical_Formula
C6H13NO2
Epsilcapramin RX_link
http://www.rxlist.com/cgi/generic/amicarpre.htm
Epsilcapramin fda sheet
Epsilcapramin msds (material safety sheet)
Epsilcapramin Synthesis Reference
No information avaliable
Epsilcapramin Molecular Weight
131.173 g/mol
Epsilcapramin Melting Point
205 oC
Epsilcapramin H2O Solubility
5.05E+005 mg/L
Epsilcapramin State
Solid
Epsilcapramin LogP
0.306
Epsilcapramin Dosage Forms
Solution for injection (containing 250 mg/mL of aminocaproic acid) and tablets (500, 1000mg)
Epsilcapramin Indication
For use in the treatment of excessive postoperative bleeding.
Epsilcapramin Pharmacology
Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity.
Epsilcapramin Absorption
Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).
Epsilcapramin side effects and Toxicity
A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD50 were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.
Epsilcapramin Patient Information
Epsilcapramin Organisms Affected
Humans and other mammals
