EACA
EACA Brand names, EACA Analogs
EACA Brand Names Mixture
- No information avaliable
EACA Chemical_Formula
C6H13NO2
EACA RX_link
http://www.rxlist.com/cgi/generic/amicarpre.htm
EACA fda sheet
EACA msds (material safety sheet)
EACA Synthesis Reference
No information avaliable
EACA Molecular Weight
131.173 g/mol
EACA Melting Point
205 oC
EACA H2O Solubility
5.05E+005 mg/L
EACA State
Solid
EACA LogP
0.306
EACA Dosage Forms
Solution for injection (containing 250 mg/mL of aminocaproic acid) and tablets (500, 1000mg)
EACA Indication
For use in the treatment of excessive postoperative bleeding.
EACA Pharmacology
Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity.
EACA Absorption
Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).
EACA side effects and Toxicity
A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD50 were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.
EACA Patient Information
EACA Organisms Affected
Humans and other mammals
