Capramol
Capramol Brand names, Capramol Analogs
Capramol Brand Names Mixture
- No information avaliable
Capramol Chemical_Formula
C6H13NO2
Capramol RX_link
http://www.rxlist.com/cgi/generic/amicarpre.htm
Capramol fda sheet
Capramol msds (material safety sheet)
Capramol Synthesis Reference
No information avaliable
Capramol Molecular Weight
131.173 g/mol
Capramol Melting Point
205 oC
Capramol H2O Solubility
5.05E+005 mg/L
Capramol State
Solid
Capramol LogP
0.306
Capramol Dosage Forms
Solution for injection (containing 250 mg/mL of aminocaproic acid) and tablets (500, 1000mg)
Capramol Indication
For use in the treatment of excessive postoperative bleeding.
Capramol Pharmacology
Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity.
Capramol Absorption
Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).
Capramol side effects and Toxicity
A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD50 were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.
Capramol Patient Information
Capramol Organisms Affected
Humans and other mammals
