Hemopar
Hemopar Brand names, Hemopar Analogs
Hemopar Brand Names Mixture
- No information avaliable
Hemopar Chemical_Formula
C6H13NO2
Hemopar RX_link
http://www.rxlist.com/cgi/generic/amicarpre.htm
Hemopar fda sheet
Hemopar msds (material safety sheet)
Hemopar Synthesis Reference
No information avaliable
Hemopar Molecular Weight
131.173 g/mol
Hemopar Melting Point
205 oC
Hemopar H2O Solubility
5.05E+005 mg/L
Hemopar State
Solid
Hemopar LogP
0.306
Hemopar Dosage Forms
Solution for injection (containing 250 mg/mL of aminocaproic acid) and tablets (500, 1000mg)
Hemopar Indication
For use in the treatment of excessive postoperative bleeding.
Hemopar Pharmacology
Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity.
Hemopar Absorption
Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).
Hemopar side effects and Toxicity
A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD50 were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.
Hemopar Patient Information
Hemopar Organisms Affected
Humans and other mammals
