Capranol
Capranol Brand names, Capranol Analogs
Capranol Brand Names Mixture
- No information avaliable
Capranol Chemical_Formula
C6H13NO2
Capranol RX_link
http://www.rxlist.com/cgi/generic/amicarpre.htm
Capranol fda sheet
Capranol msds (material safety sheet)
Capranol Synthesis Reference
No information avaliable
Capranol Molecular Weight
131.173 g/mol
Capranol Melting Point
205 oC
Capranol H2O Solubility
5.05E+005 mg/L
Capranol State
Solid
Capranol LogP
0.306
Capranol Dosage Forms
Solution for injection (containing 250 mg/mL of aminocaproic acid) and tablets (500, 1000mg)
Capranol Indication
For use in the treatment of excessive postoperative bleeding.
Capranol Pharmacology
Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity.
Capranol Absorption
Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).
Capranol side effects and Toxicity
A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD50 were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.
Capranol Patient Information
Capranol Organisms Affected
Humans and other mammals
