Acepramine
Acepramine Brand names, Acepramine Analogs
Acepramine Brand Names Mixture
- No information avaliable
Acepramine Chemical_Formula
C6H13NO2
Acepramine RX_link
http://www.rxlist.com/cgi/generic/amicarpre.htm
Acepramine fda sheet
Acepramine msds (material safety sheet)
Acepramine Synthesis Reference
No information avaliable
Acepramine Molecular Weight
131.173 g/mol
Acepramine Melting Point
205 oC
Acepramine H2O Solubility
5.05E+005 mg/L
Acepramine State
Solid
Acepramine LogP
0.306
Acepramine Dosage Forms
Solution for injection (containing 250 mg/mL of aminocaproic acid) and tablets (500, 1000mg)
Acepramine Indication
For use in the treatment of excessive postoperative bleeding.
Acepramine Pharmacology
Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity.
Acepramine Absorption
Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).
Acepramine side effects and Toxicity
A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD50 were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.
Acepramine Patient Information
Acepramine Organisms Affected
Humans and other mammals
