Amicar
Amicar Brand names, Amicar Analogs
Amicar Brand Names Mixture
- No information avaliable
Amicar Chemical_Formula
C6H13NO2
Amicar RX_link
http://www.rxlist.com/cgi/generic/amicarpre.htm
Amicar fda sheet
Amicar msds (material safety sheet)
Amicar Synthesis Reference
No information avaliable
Amicar Molecular Weight
131.173 g/mol
Amicar Melting Point
205 oC
Amicar H2O Solubility
5.05E+005 mg/L
Amicar State
Solid
Amicar LogP
0.306
Amicar Dosage Forms
Solution for injection (containing 250 mg/mL of aminocaproic acid) and tablets (500, 1000mg)
Amicar Indication
For use in the treatment of excessive postoperative bleeding.
Amicar Pharmacology
Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity.
Amicar Absorption
Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).
Amicar side effects and Toxicity
A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD50 were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.
Amicar Patient Information
Amicar Organisms Affected
Humans and other mammals
