Caplamin
Caplamin Brand names, Caplamin Analogs
Caplamin Brand Names Mixture
- No information avaliable
Caplamin Chemical_Formula
C6H13NO2
Caplamin RX_link
http://www.rxlist.com/cgi/generic/amicarpre.htm
Caplamin fda sheet
Caplamin msds (material safety sheet)
Caplamin Synthesis Reference
No information avaliable
Caplamin Molecular Weight
131.173 g/mol
Caplamin Melting Point
205 oC
Caplamin H2O Solubility
5.05E+005 mg/L
Caplamin State
Solid
Caplamin LogP
0.306
Caplamin Dosage Forms
Solution for injection (containing 250 mg/mL of aminocaproic acid) and tablets (500, 1000mg)
Caplamin Indication
For use in the treatment of excessive postoperative bleeding.
Caplamin Pharmacology
Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity.
Caplamin Absorption
Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).
Caplamin side effects and Toxicity
A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD50 were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.
Caplamin Patient Information
Caplamin Organisms Affected
Humans and other mammals
