Caprolisin

Caprolisin Brand names, Caprolisin Analogs

Caprolisin Brand Names Mixture

No information avaliable

Caprolisin Chemical_Formula

C₆H₁₃NO₂

Caprolisin RX_link

http://www.rxlist.com/cgi/generic/amicarpre.htm

Caprolisin fda sheet

Caprolisin FDA

Caprolisin msds (material safety sheet)

Caprolisin MSDS

Caprolisin Synthesis Reference

No information avaliable

Caprolisin Molecular Weight

131.173 g/mol

Caprolisin Melting Point

205 ^oC

Caprolisin H₂O Solubility

5.05E+005 mg/L

Caprolisin State

Solid

Caprolisin LogP

0.306

Caprolisin Dosage Forms

Solution for injection (containing 250 mg/mL of aminocaproic acid) and tablets (500, 1000mg)

Caprolisin Indication

For use in the treatment of excessive postoperative bleeding.

Caprolisin Pharmacology

Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity.

Caprolisin Absorption

Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).

Caprolisin side effects and Toxicity

A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD₅₀ were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.

Caprolisin Patient Information

Caprolisin Organisms Affected

Humans and other mammals