Caprocid
Caprocid Brand names, Caprocid Analogs
Caprocid Brand Names Mixture
- No information avaliable
Caprocid Chemical_Formula
C6H13NO2
Caprocid RX_link
http://www.rxlist.com/cgi/generic/amicarpre.htm
Caprocid fda sheet
Caprocid msds (material safety sheet)
Caprocid Synthesis Reference
No information avaliable
Caprocid Molecular Weight
131.173 g/mol
Caprocid Melting Point
205 oC
Caprocid H2O Solubility
5.05E+005 mg/L
Caprocid State
Solid
Caprocid LogP
0.306
Caprocid Dosage Forms
Solution for injection (containing 250 mg/mL of aminocaproic acid) and tablets (500, 1000mg)
Caprocid Indication
For use in the treatment of excessive postoperative bleeding.
Caprocid Pharmacology
Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity.
Caprocid Absorption
Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).
Caprocid side effects and Toxicity
A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD50 were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.
Caprocid Patient Information
Caprocid Organisms Affected
Humans and other mammals
