Hepin
Hepin Brand names, Hepin Analogs
Hepin Brand Names Mixture
- No information avaliable
Hepin Chemical_Formula
C6H13NO2
Hepin RX_link
http://www.rxlist.com/cgi/generic/amicarpre.htm
Hepin fda sheet
Hepin msds (material safety sheet)
Hepin Synthesis Reference
No information avaliable
Hepin Molecular Weight
131.173 g/mol
Hepin Melting Point
205 oC
Hepin H2O Solubility
5.05E+005 mg/L
Hepin State
Solid
Hepin LogP
0.306
Hepin Dosage Forms
Solution for injection (containing 250 mg/mL of aminocaproic acid) and tablets (500, 1000mg)
Hepin Indication
For use in the treatment of excessive postoperative bleeding.
Hepin Pharmacology
Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity.
Hepin Absorption
Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).
Hepin side effects and Toxicity
A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD50 were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.
Hepin Patient Information
Hepin Organisms Affected
Humans and other mammals
