Aminocaproic
Aminocaproic Brand names, Aminocaproic Analogs
Aminocaproic Brand Names Mixture
- No information avaliable
Aminocaproic Chemical_Formula
C6H13NO2
Aminocaproic RX_link
http://www.rxlist.com/cgi/generic/amicarpre.htm
Aminocaproic fda sheet
Aminocaproic msds (material safety sheet)
Aminocaproic Synthesis Reference
No information avaliable
Aminocaproic Molecular Weight
131.173 g/mol
Aminocaproic Melting Point
205 oC
Aminocaproic H2O Solubility
5.05E+005 mg/L
Aminocaproic State
Solid
Aminocaproic LogP
0.306
Aminocaproic Dosage Forms
Solution for injection (containing 250 mg/mL of aminocaproic acid) and tablets (500, 1000mg)
Aminocaproic Indication
For use in the treatment of excessive postoperative bleeding.
Aminocaproic Pharmacology
Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity.
Aminocaproic Absorption
Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).
Aminocaproic side effects and Toxicity
A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD50 were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.
Aminocaproic Patient Information
Aminocaproic Organisms Affected
Humans and other mammals
