Epsamon
Epsamon Brand names, Epsamon Analogs
Epsamon Brand Names Mixture
- No information avaliable
Epsamon Chemical_Formula
C6H13NO2
Epsamon RX_link
http://www.rxlist.com/cgi/generic/amicarpre.htm
Epsamon fda sheet
Epsamon msds (material safety sheet)
Epsamon Synthesis Reference
No information avaliable
Epsamon Molecular Weight
131.173 g/mol
Epsamon Melting Point
205 oC
Epsamon H2O Solubility
5.05E+005 mg/L
Epsamon State
Solid
Epsamon LogP
0.306
Epsamon Dosage Forms
Solution for injection (containing 250 mg/mL of aminocaproic acid) and tablets (500, 1000mg)
Epsamon Indication
For use in the treatment of excessive postoperative bleeding.
Epsamon Pharmacology
Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity.
Epsamon Absorption
Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).
Epsamon side effects and Toxicity
A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD50 were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.
Epsamon Patient Information
Epsamon Organisms Affected
Humans and other mammals
