Hemocaprol
Hemocaprol Brand names, Hemocaprol Analogs
Hemocaprol Brand Names Mixture
- No information avaliable
Hemocaprol Chemical_Formula
C6H13NO2
Hemocaprol RX_link
http://www.rxlist.com/cgi/generic/amicarpre.htm
Hemocaprol fda sheet
Hemocaprol msds (material safety sheet)
Hemocaprol Synthesis Reference
No information avaliable
Hemocaprol Molecular Weight
131.173 g/mol
Hemocaprol Melting Point
205 oC
Hemocaprol H2O Solubility
5.05E+005 mg/L
Hemocaprol State
Solid
Hemocaprol LogP
0.306
Hemocaprol Dosage Forms
Solution for injection (containing 250 mg/mL of aminocaproic acid) and tablets (500, 1000mg)
Hemocaprol Indication
For use in the treatment of excessive postoperative bleeding.
Hemocaprol Pharmacology
Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity.
Hemocaprol Absorption
Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).
Hemocaprol side effects and Toxicity
A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD50 were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.
Hemocaprol Patient Information
Hemocaprol Organisms Affected
Humans and other mammals
