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Hemocaprol Brand names, Hemocaprol Analogs

Hemocaprol Brand Names Mixture

  • No information avaliable

Hemocaprol Chemical_Formula

C6H13NO2

Hemocaprol RX_link

http://www.rxlist.com/cgi/generic/amicarpre.htm

Hemocaprol fda sheet

Hemocaprol FDA

Hemocaprol msds (material safety sheet)

Hemocaprol MSDS

Hemocaprol Synthesis Reference

No information avaliable

Hemocaprol Molecular Weight

131.173 g/mol

Hemocaprol Melting Point

205 oC

Hemocaprol H2O Solubility

5.05E+005 mg/L

Hemocaprol State

Solid

Hemocaprol LogP

0.306

Hemocaprol Dosage Forms

Solution for injection (containing 250 mg/mL of aminocaproic acid) and tablets (500, 1000mg)

Hemocaprol Indication

For use in the treatment of excessive postoperative bleeding.

Hemocaprol Pharmacology

Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity.

Hemocaprol Absorption

Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).

Hemocaprol side effects and Toxicity

A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD50 were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.

Hemocaprol Patient Information

Hemocaprol Organisms Affected

Humans and other mammals