Capracid
Capracid Brand names, Capracid Analogs
Capracid Brand Names Mixture
- No information avaliable
Capracid Chemical_Formula
C6H13NO2
Capracid RX_link
http://www.rxlist.com/cgi/generic/amicarpre.htm
Capracid fda sheet
Capracid msds (material safety sheet)
Capracid Synthesis Reference
No information avaliable
Capracid Molecular Weight
131.173 g/mol
Capracid Melting Point
205 oC
Capracid H2O Solubility
5.05E+005 mg/L
Capracid State
Solid
Capracid LogP
0.306
Capracid Dosage Forms
Solution for injection (containing 250 mg/mL of aminocaproic acid) and tablets (500, 1000mg)
Capracid Indication
For use in the treatment of excessive postoperative bleeding.
Capracid Pharmacology
Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity.
Capracid Absorption
Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).
Capracid side effects and Toxicity
A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD50 were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.
Capracid Patient Information
Capracid Organisms Affected
Humans and other mammals
