Epsicapron
Epsicapron Brand names, Epsicapron Analogs
Epsicapron Brand Names Mixture
- No information avaliable
Epsicapron Chemical_Formula
C6H13NO2
Epsicapron RX_link
http://www.rxlist.com/cgi/generic/amicarpre.htm
Epsicapron fda sheet
Epsicapron msds (material safety sheet)
Epsicapron Synthesis Reference
No information avaliable
Epsicapron Molecular Weight
131.173 g/mol
Epsicapron Melting Point
205 oC
Epsicapron H2O Solubility
5.05E+005 mg/L
Epsicapron State
Solid
Epsicapron LogP
0.306
Epsicapron Dosage Forms
Solution for injection (containing 250 mg/mL of aminocaproic acid) and tablets (500, 1000mg)
Epsicapron Indication
For use in the treatment of excessive postoperative bleeding.
Epsicapron Pharmacology
Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity.
Epsicapron Absorption
Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).
Epsicapron side effects and Toxicity
A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD50 were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.
Epsicapron Patient Information
Epsicapron Organisms Affected
Humans and other mammals
