N-Phthalylglutamic acid imide
Brand names,
N-Phthalylglutamic acid imide
Analogs
N-Phthalylglutamic acid imide
Brand Names Mixture
N-Phthalylglutamic acid imide
Chemical_Formula
C16H13Cl3N2OS
N-Phthalylglutamic acid imide
RX_link
http://www.rxlist.com/cgi/generic3/tioconaz.htm
N-Phthalylglutamic acid imide
fda sheet
N-Phthalylglutamic acid imide
msds (material safety sheet)
N-Phthalylglutamic acid imide
Synthesis Reference
No information avaliable
N-Phthalylglutamic acid imide
Molecular Weight
387.711 g/mol
N-Phthalylglutamic acid imide
Melting Point
No information avaliable
N-Phthalylglutamic acid imide
H2O Solubility
No information avaliable
N-Phthalylglutamic acid imide
State
Solid
N-Phthalylglutamic acid imide
LogP
4.971
N-Phthalylglutamic acid imide
Dosage Forms
Cream; Ointment; Suppository (each applicator-full provides approximately 4.6 grams of ointment containing 300 mg of tioconazole)
N-Phthalylglutamic acid imide
Indication
For the local treatment of vulvovaginal candidiasis (moniliasis).
N-Phthalylglutamic acid imide
Pharmacology
Tioconazole is a broad-spectrum imidazole antifungal agent that inhibits the growth of human pathogenic yeasts. Tioconazole exhibits fungicidal activity in vitro against Candida albicans, other species of the genus Candida, and against Torulopsis glabrata. Tioconazole prevents the growth and function of some fungal organisms by interfering with the production of substances needed to preserve the cell membrane. This drug is effective only for infections caused by fungal organisms. It will not work for bacterial or viral infections.
N-Phthalylglutamic acid imide
Absorption
Systemic absorption following a single intravaginal application of tioconazole in nonpregnant patients is negligible.
N-Phthalylglutamic acid imide
side effects and Toxicity
Symptoms of overdose include erythema, stinging, blistering, peeling, edema, pruritus, urticaria, burning,
N-Phthalylglutamic acid imide
Patient Information
N-Phthalylglutamic acid imide
Organisms Affected
Yeast and other fungi