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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C16H13Cl3N2OS
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RX_link
http://www.rxlist.com/cgi/generic3/tioconaz.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
387.711 g/mol
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Melting Point
No information avaliable
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H2O Solubility
No information avaliable
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State
Solid
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LogP
4.971
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Dosage Forms
Cream; Ointment; Suppository (each applicator-full provides approximately 4.6 grams of ointment containing 300 mg of tioconazole)
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Indication
For the local treatment of vulvovaginal candidiasis (moniliasis).
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Pharmacology
Tioconazole is a broad-spectrum imidazole antifungal agent that inhibits the growth of human pathogenic yeasts. Tioconazole exhibits fungicidal activity in vitro against Candida albicans, other species of the genus Candida, and against Torulopsis glabrata. Tioconazole prevents the growth and function of some fungal organisms by interfering with the production of substances needed to preserve the cell membrane. This drug is effective only for infections caused by fungal organisms. It will not work for bacterial or viral infections.
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Absorption
Systemic absorption following a single intravaginal application of tioconazole in nonpregnant patients is negligible.
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side effects and Toxicity
Symptoms of overdose include erythema, stinging, blistering, peeling, edema, pruritus, urticaria, burning,
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Patient Information
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Organisms Affected
Yeast and other fungi