Contergan
Brand names,
Contergan
Analogs
Contergan
Brand Names Mixture
Contergan
Chemical_Formula
C16H13Cl3N2OS
Contergan
RX_link
http://www.rxlist.com/cgi/generic3/tioconaz.htm
Contergan
fda sheet
Contergan
msds (material safety sheet)
Contergan
Synthesis Reference
No information avaliable
Contergan
Molecular Weight
387.711 g/mol
Contergan
Melting Point
No information avaliable
Contergan
H2O Solubility
No information avaliable
Contergan
State
Solid
Contergan
LogP
4.971
Contergan
Dosage Forms
Cream; Ointment; Suppository (each applicator-full provides approximately 4.6 grams of ointment containing 300 mg of tioconazole)
Contergan
Indication
For the local treatment of vulvovaginal candidiasis (moniliasis).
Contergan
Pharmacology
Tioconazole is a broad-spectrum imidazole antifungal agent that inhibits the growth of human pathogenic yeasts. Tioconazole exhibits fungicidal activity in vitro against Candida albicans, other species of the genus Candida, and against Torulopsis glabrata. Tioconazole prevents the growth and function of some fungal organisms by interfering with the production of substances needed to preserve the cell membrane. This drug is effective only for infections caused by fungal organisms. It will not work for bacterial or viral infections.
Contergan
Absorption
Systemic absorption following a single intravaginal application of tioconazole in nonpregnant patients is negligible.
Contergan
side effects and Toxicity
Symptoms of overdose include erythema, stinging, blistering, peeling, edema, pruritus, urticaria, burning,
Contergan
Patient Information
Contergan
Organisms Affected
Yeast and other fungi