Methylprednisolone, Pharma
Brand names,
Methylprednisolone, Pharma
Analogs
Methylprednisolone, Pharma
Brand Names Mixture
- Depo-Medrol with Lidocaine (Lidocaine Hydrochloride + Methylprednisolone Acetate)
- Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Sulfur)
- Methylprednisolone Sodium Succinate for Injection (Methylprednisolone + Water)
- Neo-Medrol (Methylprednisolone Acetate + Neomycin Sulfate)
- Neo-Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Neomycin Sulfate + Sulfur)
Methylprednisolone, Pharma
Chemical_Formula
C22H30O5
Methylprednisolone, Pharma
RX_link
http://www.rxlist.com/cgi/generic/methprd.htm
Methylprednisolone, Pharma
fda sheet
Methylprednisolone, Pharma
msds (material safety sheet)
Methylprednisolone, Pharma
Synthesis Reference
Sebek, Spero, U.S. Pat. 2,897,218 (1959)
Methylprednisolone, Pharma
Molecular Weight
374.471 g/mol
Methylprednisolone, Pharma
Melting Point
232.5 oC
Methylprednisolone, Pharma
H2O Solubility
120 mg/L
Methylprednisolone, Pharma
State
Solid
Methylprednisolone, Pharma
LogP
2.134
Methylprednisolone, Pharma
Dosage Forms
Tablets; Suspension
Methylprednisolone, Pharma
Indication
Adjunctive therapy for short-term administration in rheumatoid arthritis.
Methylprednisolone, Pharma
Pharmacology
Methylprednisolone and its derivatives, methylprednisolone sodium succinate and methylprednisolone acetate, are synthetic glucocorticoids used as antiinflammatory or immunosuppressive agents.
Methylprednisolone, Pharma
Absorption
Oral bioavailability 80-99%
Methylprednisolone, Pharma
side effects and Toxicity
LD50=2000 mg/kg (orally in rat)
Methylprednisolone, Pharma
Patient Information
Persons who are on immunosuppressant doses of corticosteroids should be warned to avoid exposure to chicken pox or
measles. Patients should also be advised that if they are exposed, medical advice should be sought without delay.
Methylprednisolone, Pharma
Organisms Affected
Humans and other mammals