Promacortine
Brand names,
Promacortine
Analogs
Promacortine
Brand Names Mixture
- Depo-Medrol with Lidocaine (Lidocaine Hydrochloride + Methylprednisolone Acetate)
- Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Sulfur)
- Methylprednisolone Sodium Succinate for Injection (Methylprednisolone + Water)
- Neo-Medrol (Methylprednisolone Acetate + Neomycin Sulfate)
- Neo-Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Neomycin Sulfate + Sulfur)
Promacortine
Chemical_Formula
C22H30O5
Promacortine
RX_link
http://www.rxlist.com/cgi/generic/methprd.htm
Promacortine
fda sheet
Promacortine
msds (material safety sheet)
Promacortine
Synthesis Reference
Sebek, Spero, U.S. Pat. 2,897,218 (1959)
Promacortine
Molecular Weight
374.471 g/mol
Promacortine
Melting Point
232.5 oC
Promacortine
H2O Solubility
120 mg/L
Promacortine
State
Solid
Promacortine
LogP
2.134
Promacortine
Dosage Forms
Tablets; Suspension
Promacortine
Indication
Adjunctive therapy for short-term administration in rheumatoid arthritis.
Promacortine
Pharmacology
Methylprednisolone and its derivatives, methylprednisolone sodium succinate and methylprednisolone acetate, are synthetic glucocorticoids used as antiinflammatory or immunosuppressive agents.
Promacortine
Absorption
Oral bioavailability 80-99%
Promacortine
side effects and Toxicity
LD50=2000 mg/kg (orally in rat)
Promacortine
Patient Information
Persons who are on immunosuppressant doses of corticosteroids should be warned to avoid exposure to chicken pox or
measles. Patients should also be advised that if they are exposed, medical advice should be sought without delay.
Promacortine
Organisms Affected
Humans and other mammals