Sieropresol
Brand names,
Sieropresol
Analogs
Sieropresol
Brand Names Mixture
- Depo-Medrol with Lidocaine (Lidocaine Hydrochloride + Methylprednisolone Acetate)
- Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Sulfur)
- Methylprednisolone Sodium Succinate for Injection (Methylprednisolone + Water)
- Neo-Medrol (Methylprednisolone Acetate + Neomycin Sulfate)
- Neo-Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Neomycin Sulfate + Sulfur)
Sieropresol
Chemical_Formula
C22H30O5
Sieropresol
RX_link
http://www.rxlist.com/cgi/generic/methprd.htm
Sieropresol
fda sheet
Sieropresol
msds (material safety sheet)
Sieropresol
Synthesis Reference
Sebek, Spero, U.S. Pat. 2,897,218 (1959)
Sieropresol
Molecular Weight
374.471 g/mol
Sieropresol
Melting Point
232.5 oC
Sieropresol
H2O Solubility
120 mg/L
Sieropresol
State
Solid
Sieropresol
LogP
2.134
Sieropresol
Dosage Forms
Tablets; Suspension
Sieropresol
Indication
Adjunctive therapy for short-term administration in rheumatoid arthritis.
Sieropresol
Pharmacology
Methylprednisolone and its derivatives, methylprednisolone sodium succinate and methylprednisolone acetate, are synthetic glucocorticoids used as antiinflammatory or immunosuppressive agents.
Sieropresol
Absorption
Oral bioavailability 80-99%
Sieropresol
side effects and Toxicity
LD50=2000 mg/kg (orally in rat)
Sieropresol
Patient Information
Persons who are on immunosuppressant doses of corticosteroids should be warned to avoid exposure to chicken pox or
measles. Patients should also be advised that if they are exposed, medical advice should be sought without delay.
Sieropresol
Organisms Affected
Humans and other mammals