6alpha-Methylprednisolone
Brand names,
6alpha-Methylprednisolone
Analogs
6alpha-Methylprednisolone
Brand Names Mixture
- Depo-Medrol with Lidocaine (Lidocaine Hydrochloride + Methylprednisolone Acetate)
- Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Sulfur)
- Methylprednisolone Sodium Succinate for Injection (Methylprednisolone + Water)
- Neo-Medrol (Methylprednisolone Acetate + Neomycin Sulfate)
- Neo-Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Neomycin Sulfate + Sulfur)
6alpha-Methylprednisolone
Chemical_Formula
C22H30O5
6alpha-Methylprednisolone
RX_link
http://www.rxlist.com/cgi/generic/methprd.htm
6alpha-Methylprednisolone
fda sheet
6alpha-Methylprednisolone
msds (material safety sheet)
6alpha-Methylprednisolone
Synthesis Reference
Sebek, Spero, U.S. Pat. 2,897,218 (1959)
6alpha-Methylprednisolone
Molecular Weight
374.471 g/mol
6alpha-Methylprednisolone
Melting Point
232.5 oC
6alpha-Methylprednisolone
H2O Solubility
120 mg/L
6alpha-Methylprednisolone
State
Solid
6alpha-Methylprednisolone
LogP
2.134
6alpha-Methylprednisolone
Dosage Forms
Tablets; Suspension
6alpha-Methylprednisolone
Indication
Adjunctive therapy for short-term administration in rheumatoid arthritis.
6alpha-Methylprednisolone
Pharmacology
Methylprednisolone and its derivatives, methylprednisolone sodium succinate and methylprednisolone acetate, are synthetic glucocorticoids used as antiinflammatory or immunosuppressive agents.
6alpha-Methylprednisolone
Absorption
Oral bioavailability 80-99%
6alpha-Methylprednisolone
side effects and Toxicity
LD50=2000 mg/kg (orally in rat)
6alpha-Methylprednisolone
Patient Information
Persons who are on immunosuppressant doses of corticosteroids should be warned to avoid exposure to chicken pox or
measles. Patients should also be advised that if they are exposed, medical advice should be sought without delay.
6alpha-Methylprednisolone
Organisms Affected
Humans and other mammals