Medlone 21
Brand names,
Medlone 21
Analogs
Medlone 21
Brand Names Mixture
- Depo-Medrol with Lidocaine (Lidocaine Hydrochloride + Methylprednisolone Acetate)
- Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Sulfur)
- Methylprednisolone Sodium Succinate for Injection (Methylprednisolone + Water)
- Neo-Medrol (Methylprednisolone Acetate + Neomycin Sulfate)
- Neo-Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Neomycin Sulfate + Sulfur)
Medlone 21
Chemical_Formula
C22H30O5
Medlone 21
RX_link
http://www.rxlist.com/cgi/generic/methprd.htm
Medlone 21
fda sheet
Medlone 21
msds (material safety sheet)
Medlone 21
Synthesis Reference
Sebek, Spero, U.S. Pat. 2,897,218 (1959)
Medlone 21
Molecular Weight
374.471 g/mol
Medlone 21
Melting Point
232.5 oC
Medlone 21
H2O Solubility
120 mg/L
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State
Solid
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LogP
2.134
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Dosage Forms
Tablets; Suspension
Medlone 21
Indication
Adjunctive therapy for short-term administration in rheumatoid arthritis.
Medlone 21
Pharmacology
Methylprednisolone and its derivatives, methylprednisolone sodium succinate and methylprednisolone acetate, are synthetic glucocorticoids used as antiinflammatory or immunosuppressive agents.
Medlone 21
Absorption
Oral bioavailability 80-99%
Medlone 21
side effects and Toxicity
LD50=2000 mg/kg (orally in rat)
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Patient Information
Persons who are on immunosuppressant doses of corticosteroids should be warned to avoid exposure to chicken pox or
measles. Patients should also be advised that if they are exposed, medical advice should be sought without delay.
Medlone 21
Organisms Affected
Humans and other mammals