MEPRDL
Brand names,
MEPRDL
Analogs
MEPRDL
Brand Names Mixture
- Depo-Medrol with Lidocaine (Lidocaine Hydrochloride + Methylprednisolone Acetate)
- Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Sulfur)
- Methylprednisolone Sodium Succinate for Injection (Methylprednisolone + Water)
- Neo-Medrol (Methylprednisolone Acetate + Neomycin Sulfate)
- Neo-Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Neomycin Sulfate + Sulfur)
MEPRDL
Chemical_Formula
C22H30O5
MEPRDL
RX_link
http://www.rxlist.com/cgi/generic/methprd.htm
MEPRDL
fda sheet
MEPRDL
msds (material safety sheet)
MEPRDL
Synthesis Reference
Sebek, Spero, U.S. Pat. 2,897,218 (1959)
MEPRDL
Molecular Weight
374.471 g/mol
MEPRDL
Melting Point
232.5 oC
MEPRDL
H2O Solubility
120 mg/L
MEPRDL
State
Solid
MEPRDL
LogP
2.134
MEPRDL
Dosage Forms
Tablets; Suspension
MEPRDL
Indication
Adjunctive therapy for short-term administration in rheumatoid arthritis.
MEPRDL
Pharmacology
Methylprednisolone and its derivatives, methylprednisolone sodium succinate and methylprednisolone acetate, are synthetic glucocorticoids used as antiinflammatory or immunosuppressive agents.
MEPRDL
Absorption
Oral bioavailability 80-99%
MEPRDL
side effects and Toxicity
LD50=2000 mg/kg (orally in rat)
MEPRDL
Patient Information
Persons who are on immunosuppressant doses of corticosteroids should be warned to avoid exposure to chicken pox or
measles. Patients should also be advised that if they are exposed, medical advice should be sought without delay.
MEPRDL
Organisms Affected
Humans and other mammals