Nirypan
Brand names,
Nirypan
Analogs
Nirypan
Brand Names Mixture
- Depo-Medrol with Lidocaine (Lidocaine Hydrochloride + Methylprednisolone Acetate)
- Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Sulfur)
- Methylprednisolone Sodium Succinate for Injection (Methylprednisolone + Water)
- Neo-Medrol (Methylprednisolone Acetate + Neomycin Sulfate)
- Neo-Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Neomycin Sulfate + Sulfur)
Nirypan
Chemical_Formula
C22H30O5
Nirypan
RX_link
http://www.rxlist.com/cgi/generic/methprd.htm
Nirypan
fda sheet
Nirypan
msds (material safety sheet)
Nirypan
Synthesis Reference
Sebek, Spero, U.S. Pat. 2,897,218 (1959)
Nirypan
Molecular Weight
374.471 g/mol
Nirypan
Melting Point
232.5 oC
Nirypan
H2O Solubility
120 mg/L
Nirypan
State
Solid
Nirypan
LogP
2.134
Nirypan
Dosage Forms
Tablets; Suspension
Nirypan
Indication
Adjunctive therapy for short-term administration in rheumatoid arthritis.
Nirypan
Pharmacology
Methylprednisolone and its derivatives, methylprednisolone sodium succinate and methylprednisolone acetate, are synthetic glucocorticoids used as antiinflammatory or immunosuppressive agents.
Nirypan
Absorption
Oral bioavailability 80-99%
Nirypan
side effects and Toxicity
LD50=2000 mg/kg (orally in rat)
Nirypan
Patient Information
Persons who are on immunosuppressant doses of corticosteroids should be warned to avoid exposure to chicken pox or
measles. Patients should also be advised that if they are exposed, medical advice should be sought without delay.
Nirypan
Organisms Affected
Humans and other mammals