Metilbetasone
Brand names,
Metilbetasone
Analogs
Metilbetasone
Brand Names Mixture
- Depo-Medrol with Lidocaine (Lidocaine Hydrochloride + Methylprednisolone Acetate)
- Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Sulfur)
- Methylprednisolone Sodium Succinate for Injection (Methylprednisolone + Water)
- Neo-Medrol (Methylprednisolone Acetate + Neomycin Sulfate)
- Neo-Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Neomycin Sulfate + Sulfur)
Metilbetasone
Chemical_Formula
C22H30O5
Metilbetasone
RX_link
http://www.rxlist.com/cgi/generic/methprd.htm
Metilbetasone
fda sheet
Metilbetasone
msds (material safety sheet)
Metilbetasone
Synthesis Reference
Sebek, Spero, U.S. Pat. 2,897,218 (1959)
Metilbetasone
Molecular Weight
374.471 g/mol
Metilbetasone
Melting Point
232.5 oC
Metilbetasone
H2O Solubility
120 mg/L
Metilbetasone
State
Solid
Metilbetasone
LogP
2.134
Metilbetasone
Dosage Forms
Tablets; Suspension
Metilbetasone
Indication
Adjunctive therapy for short-term administration in rheumatoid arthritis.
Metilbetasone
Pharmacology
Methylprednisolone and its derivatives, methylprednisolone sodium succinate and methylprednisolone acetate, are synthetic glucocorticoids used as antiinflammatory or immunosuppressive agents.
Metilbetasone
Absorption
Oral bioavailability 80-99%
Metilbetasone
side effects and Toxicity
LD50=2000 mg/kg (orally in rat)
Metilbetasone
Patient Information
Persons who are on immunosuppressant doses of corticosteroids should be warned to avoid exposure to chicken pox or
measles. Patients should also be advised that if they are exposed, medical advice should be sought without delay.
Metilbetasone
Organisms Affected
Humans and other mammals